Gene therapy of Cav1.2 channel with VIP and VIP receptor agonists and antagonists: a novel approach to designing promotility and antimotility agents

摘要

ion channels play a critical role in regulating cellular functions in excitable cells. Defects in ion channel function (ctian-nelopathy) contribute to diseases, such as muscular dystrophy, multiple sclerosis, and motility dysfunction in gut inflammation (4, 25, 39, 42). Channelopathy may result from gene mutation or epigenetic dysfunction resulting in deregulation of gene transcription (46). The microenvironmental stimuli, such as hormones, inflammatory mediators, neurotransmitters, and growth factors regulate the constitutive transcription of several genes to maintain normal cellular function (15, 23, 26, 33, 38, 40). Consequently, alterations in cellular microenvironment may cause transcriptional channelopathy and cellular dysfunction.