Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart

摘要

In this regard, Gauthier et al. (4, 5) recently identified and characterized a unique EET antagonist, 14,15-epoxyeicosa-5(Z)-enoic acid (EEZE). 14,15-EEZE behaves as a direct EET antagonist at a receptor binding site on the cell membrane or intracellularly (30) and antagonizes selectively many of the vascular actions of the EETs (4, 5, 29), although one study in mesenteric artery demonstrated that 14,15-EEZE had intrinsic vasodilator activity (8). However, the effects of 14,15-EEZE on the cardioprotective actions of the EETs have not been thoroughly addressed and are a major focus of the present study.