Role of sarcolemmal ATP-sensitive potassium channel in oxidative stress-induced apoptosis: mitochondrial connection

摘要

In humans the data are sparse, and only recently was a human disease linked to mutations within the cardiac sarcKATp channel (4, 33). Missense and frameshift mutations were identified within the SUR2A channel subunit in patients suffering from severe idiopathic dilated cardiomyopathy (4). However, the mechanistic link between sarcKATP channel dysfunction and heart failure is not elucidated. Although apoptosis was shown to play a critical role in the onset and progression of cardiovascular disease such as heart failure (26, 30) and myo-cardial infarction (22, 23), up to now no studies have examined the role of sarcKATP channels in apoptotic cell death.