An expanding role of Toll-like receptors in sepsis-induced acute kidney injury

摘要

Our understanding of human sepsis is driven to a certain degree by the animal models utilized. It is very important to fully understand all the implications of a specific model and to carefully examine the end points investigated: cytokine generation, organ pathology, or overall mortality. Therapeutic maneuvers might alter cytokine profiles and reduce organ damage without affecting overall mortality. It is very possible therefore that no treatment of sepsis will acquire silver bullet status. Human sepsis is a very complex condition, and it is very likely that its treatment will remain multifaceted.