Effects of hindbrain melanin-concentrating hormone and neuropeptide Y administration on licking for water, saccharin, and sucrose solutions

摘要

Recently, we characterized the effects of NPY and MCH delivery to the third ventricle (3V) on intake and licking microstructure (described below) for a range of taste solutions (water, saccharin, and sucrose solutions) that varied in palat-ability and caloric content (7, 9). If the MCH system at least partially mediates the influences of NPY, one may hypothesize that the patterns of licking responses to these two hyperphagic compounds would share some similarities, but this does not appear to be the case. While 3V or lateral ventricle (LV) applications of either NPY or MCH increase intake for many tastants, the behavioral underpinnings of these effects appear distinct.