Moving closer to an understanding of the hyperfiltration of type 2 diabetes mellitus

摘要

the nephropathy of type 2 diabetes mellitus (DM2) is the single largest cause of complete kidney failure requiring replacement therapy (stage 5 kidney disease) in industrialized countries (13). It has long been suspected that the elevated glomerular filtration rate (GFR) of early diabetic nephropathy contributes to the progressive nephropathy with subsequent GFR decline experienced by some DM2 patients (5). Identifying mechanisms(s) for this so-called hyperfiltration of early DM2 nephropathy might help identify mechanisms of nephropathy progression and lead to therapeutic strategies that prevent this most common cause of complete kidney failure. Nevertheless, most insights into the disturbed hemodynamics of#