Visible-Light Photoredox-Catalyzed Giese Reaction: Decarboxylative Addition of Amino Acid Derived -Amino Radicals to Electron-Deficient Olefins

摘要

A tin- and halide-free, visible-light photoredox-catalyzed Giese reaction was developed. Primary and secondary -amino radicals were generated readily from amino acids in the presence of catalytic amounts of an iridium photocatalyst. The reactivity of the -amino radicals has been evaluated for the functionalization of a variety of activated olefins.