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Towards Self-Assembled Hybrid Artificial Cells: Novel Bottom-Up Approaches to Functional Synthetic Membranes

机译:走向自我组装的混合人工细胞:功能合成膜的新的自下而上的方法。

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摘要

There has been increasing interest in utilizing bottom-up approaches to develop synthetic cells. A popular methodology is the integration of functionalized synthetic membranes with biological systems, producing hybrid artificial cells. This Concept article covers recent advances and the current state-of-the-art of such hybrid systems. Specifically, we describe minimal supramolecular constructs that faithfully mimic the structure and/or function of living cells, often by controlling the assembly of highly ordered membrane architectures with defined functionality. These studies give us a deeper understanding of the nature of living systems, bring new insights into the origin of cellular life, and provide novel synthetic chassis for advancing synthetic biology.
机译:利用自下而上的方法开发合成细胞的兴趣日益增加。一种流行的方法是将功能化的合成膜与生物系统整合,产生杂交的人造细胞。这篇“概念”文章介绍了此类混合系统的最新进展和当前技术水平。具体而言,我们描述了通常通过控制具有定义功能的高度有序的膜结构的组装,忠实模拟活细胞的结构和/或功能的最小超分子构建体。这些研究使我们对生命系统的本质有了更深入的了解,为细胞生命的起源带来了新见解,并为推进合成生物学提供了新颖的合成底盘。

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