Development of metal/organo catalytic systems for direct vinylogous michael reactions to build chiral γ,γ-disubstituted butenolides

摘要

Vinylogous reactions: The direct asymmetric vinylogous conjugate additions of γ-aryl- and alkyl-substituted butenolides to enones was realized for the first time by a designed and tested metal/organo dual-activation strategy, in which two effective metal/organo cooperative catalytic systems have been built (see scheme).