Zinc-catalyzed dehydrogenative N-silylation of indoles with hydrosilanes

摘要

Zinc catalysis: Zinc triflate in a nitrile solvent behaved as an effective catalyst for dehydrogenative N-silylation with a variety of indoles and hydrosilanes (see scheme). The addition of pyridine greatly accelerated the N-silylation reaction to produce N-silylindoles exclusively in high to excellent yields.