Synthesis of trifluorostyrene derivatives by palladium-catalyzed cross-coupling of lithium trimethoxy(trifluorovinyl)borate with aryl bromides

摘要

Fluor-ing it: The stable, crystalline trimethoxy(trifluorovinyl)borate is a convenient reagent for efficiently displacing a bromine atom with a trifluorovinyl group (see scheme). This Suzuki coupling reaction significantly simplifies the route to trifluorostyrenes, which might be interesting compounds for materials science or medicinal chemistry.