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首页> 外文期刊>Corrosion Reviews >ORTHOPEDIC IMPLANT FRETTING CORROSION
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ORTHOPEDIC IMPLANT FRETTING CORROSION

机译:骨科植入物腐蚀

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摘要

Fretting corrosion occurs to some extent on all load bearing metallic orthopedic implants. Fretting of total hip and knee replacements occurs at such places as the bone-stem interface, the stem-cement interface, and on the interfaces of modular connections between implant components. Fretting also occurs at areas of cyclic load bearing contact on metallic bone-plates and screws, such as screw-plate connections, bone-plate interfaces and screw-bone interfaces. Of primary clinical concern is the generation of ionic and particulate debris through fracture and abrasion of the metal oxide protective layers covering implant alloys /1/. This debris produced locally within crevices of component connections can migrate away from junctions and cause injury both systemically and in the local tissue. Clinical concern about the release and distribution of metallic degradation products is justified by the known potential toxicities of the elements used in modern orthopedic implant alloys (titanium, aluminum, vanadium, cobalt, chromium, molybdenum and nickel) and known pathologies associated with metal implant degradation (i.e. hypersensitivity, particle induced inflammation, etc.) /2/. However, little is known of the short and long-term biologic impact of soluble metal-protein complexes formed from the degradation products of implants.
机译:所有承重的金属骨科植入物都会在一定程度上发生微动腐蚀。全部髋关节和膝关节置换物的微动发生在诸如骨干界面,干骨水泥界面以及植入物组件之间的模块化连接界面上。微动也发生在金属骨板和螺钉上的周期性载荷接触区域,例如,螺钉板连接,骨板接口和螺钉-骨接口。临床上最主要的关注是由于覆盖植入物合金1/1 /的金属氧化物保护层的断裂和磨损而产生的离子和微粒碎片。在组件连接的缝隙中局部产生的碎片可能会从连接处移走,从而导致系统性损伤和局部组织损伤。关于金属降解产物的释放和分布的临床关注,可以通过现代骨科植入物合金(钛,铝,钒,钴,铬,钼和镍)中所用元素的已知潜在毒性以及与金属植入物降解相关的已知病理来证明(即超敏反应,颗粒诱发的炎症等)/ 2 /。然而,对于由植入物的降解产物形成的可溶性金属-蛋白质复合物的短期和长期生物学影响知之甚少。

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