DNA Damage Repair Pathway Alterations in Multiple Myeloma Predict Poor Prognosis, but Correlate with Sensitivity to IGF1R-PI3K-mTOR and HDAC Inhibitors

Majumder Muntasir M.; Tamborero David; Anttila Pekka; Silvennoinen Raija; Eldfors Samuli; Kumar Ashwini; Lievonen Juha; Parsons Alun; Suvela Minna; Jantunen Esa; Porkka Kimmo; Heckman Caroline A.

首页> 外文期刊>Blood: The Journal of the American Society of Hematology >DNA Damage Repair Pathway Alterations in Multiple Myeloma Predict Poor Prognosis, but Correlate with Sensitivity to IGF1R-PI3K-mTOR and HDAC Inhibitors

【24h】

DNA Damage Repair Pathway Alterations in Multiple Myeloma Predict Poor Prognosis, but Correlate with Sensitivity to IGF1R-PI3K-mTOR and HDAC Inhibitors

机译：多发性骨髓瘤中的DNA损伤修复途径改变可预测不良预后，但与对IGF1R-PI3K-mTOR和HDAC抑制剂的敏感性相关

获取原文

获取原文并翻译 | 示例

获取外文期刊封面目录资料

开具论文收录证明 >>

文献代查 >>

文献数据库（团队版） >>

页面导航

著录项
引文网络
相似文献
相关主题

著录项

来源
《Blood: The Journal of the American Society of Hematology》 |2016年第22期|共4页
作者
Majumder Muntasir M.; Tamborero David; Anttila Pekka; Silvennoinen Raija; Eldfors Samuli; Kumar Ashwini; Lievonen Juha; Parsons Alun; Suvela Minna; Jantunen Esa; Porkka Kimmo; Heckman Caroline A.;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类
关键词

相似文献

外文文献
中文文献
专利

1. DNA Damage Repair Pathway Alterations in Multiple Myeloma Predict Poor Prognosis, but Correlate with Sensitivity to IGF1R-PI3K-mTOR and HDAC Inhibitors [J] . Majumder Muntasir M., Tamborero David, Anttila Pekka, Blood: The Journal of the American Society of Hematology . 2016,第22期

机译：多发性骨髓瘤中的DNA损伤修复途径改变可预测不良预后，但与对IGF1R-PI3K-mTOR和HDAC抑制剂的敏感性相关
2. PJ34, a poly(ADP-ribose) polymerase (PARP) inhibitor, reverses melphalan-resistance and inhibits repair of DNA double-strand breaks by targeting the FA/BRCA pathway in multidrug resistant multiple myeloma cell line RPMI8226/R [J] . Ting Xiong, Heng Wei, Xiaoqiong Chen, International journal of oncology . 2014,第1期

机译：PJ34，一种多聚（ADP-核糖）聚合酶（PARP）抑制剂，通过靶向多药耐药性多发性骨髓瘤细胞系RPMI8226 / R中的FA / BRCA途径，逆转耐甲氧苯丙酸并抑制DNA双链断裂的修复。
3. Re: Oda et al. Frequent alteration of p16~(INK4a)/p14~(ARF) and p53 pathways in the round cell component of myxoid/round cell liposarcoma: pS3 gene alterations and reduced p14~(ARF) expression both correlate with poor prognosis [J] . F Perrone, E Tamborini, S Suardi Journal of Pathology: Journal of the Pathological Society of Great Britain and Ireland . 2006,第2期

机译：回复：小田等。粘液样/圆形细胞脂肪肉瘤圆形细胞成分中p16〜（INK4a）/ p14〜（ARF）和p53途径的频繁改变：pS3基因改变和p14〜（ARF）表达降低均与不良预后相关
4. rSNP_Guide: Meta-Tools Predicting of Regulatory DNA Signals Damaged/Appeared Due to Single Nucleotide Mutation by Alterations in Pattern of DNA Binding to Nuclear Proteins [C] . Mikhail Ponomarenko, Tatyana Merkulova, Julia Ponomarenko, International NAISO(Natural amp; Artificial Intelligence Systems Organization) Congress on Information Science Innovations Mar 17-21, 2001 Dubai, U.A.E. . 2001

机译：rSNP_Guide：预测由于单核苷酸突变导致DNA结合核蛋白模式改变而破坏/显示的调控DNA信号的元工具
5. The Fanconi anemia (FA)/BRCA DNA damage repair pathway is regulated by NF-kappaB and mediates drug resistance in multiple myeloma. [D] . Yarde, Danielle N. 2010

机译：范可尼贫血（FA）/ BRCA DNA损伤修复途径受NF-κB调节并介导多发性骨髓瘤的耐药性。
6. Overexpression of karyopherin-α2 in cholangiocarcinoma correlates with poor prognosis and gemcitabine sensitivity via nuclear translocation of DNA repair proteins [O] . Mariko Tsukagoshi, Kenichiro Araki, Takehiko Yokobori, 2017

机译：通过核修复DNA修复蛋白胆管癌中核蛋白-α2的过表达与预后不良和吉西他滨敏感性相关
7. A Comprehensive Analysis of Alterations in DNA Damage Repair Pathways Reveals a Potential Way to Enhance the Radio-Sensitivity of Esophageal Squamous Cell Cancer [O] . Guangchao Wang, Shichao Guo, Weimin Zhang, 2020

机译：综合分析DNA损伤修复途径的改变揭示了增强食管鳞状细胞癌的无线电敏感性的潜在方法

DNA Damage Repair Pathway Alterations in Multiple Myeloma Predict Poor Prognosis, but Correlate with Sensitivity to IGF1R-PI3K-mTOR and HDAC Inhibitors

著录项

引文网络

相似文献

相关主题

期刊订阅