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首页> 外文期刊>Blood: The Journal of the American Society of Hematology >The Effects of the Neutrophil Elastase Inhibitors MK0339 and Sivelestat on the Survival, Proliferation and Maturation of iPSC and HL60 Cells Expressing Mutant Neutrophil Elastase

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The Effects of the Neutrophil Elastase Inhibitors MK0339 and Sivelestat on the Survival, Proliferation and Maturation of iPSC and HL60 Cells Expressing Mutant Neutrophil Elastase

机译：中性粒细胞弹性蛋白酶抑制剂MK0339和Sivelestat对表达突变型中性粒细胞弹性蛋白酶的iPSC和HL60细胞的存活，增殖和成熟的影响

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《Blood: The Journal of the American Society of Hematology》 |2016年第22期|共6页
作者
Makaryan Vahagn; Kelley Merideth L.; Fletcher Breanna; Dale David C.;
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1. The Effects of the Neutrophil Elastase Inhibitors MK0339 and Sivelestat on the Survival, Proliferation and Maturation of iPSC and HL60 Cells Expressing Mutant Neutrophil Elastase [J] . Makaryan Vahagn, Kelley Merideth L., Fletcher Breanna, Blood: The Journal of the American Society of Hematology . 2016,第22期

机译：中性粒细胞弹性蛋白酶抑制剂MK0339和Sivelestat对表达突变型中性粒细胞弹性蛋白酶的iPSC和HL60细胞的存活，增殖和成熟的影响
2. Sivelestat, a specific neutrophil elastase inhibitor, suppresses the growth of gastric carcinoma cells by preventing the release of transforming growth factor-alpha. [J] . Wada Y, Yoshida K, Hihara J, Cancer science. . 2006,第10期

机译：Sivelestat是一种特定的嗜中性粒细胞弹性蛋白酶抑制剂，它通过阻止转化生长因子-α的释放来抑制胃癌细胞的生长。
3. CRISPR/Cas9 Knock-in HL60 Cells Closely Simulate Cellular and Functional Abnormalities of ELANEassociated Neutropenia; Phenotype Rescue with MK-0339 Neutrophil Elastase Inhibitor [J] . Makaryan Vahagn, Fletcher Breanna, Kelley Merideth L., Blood: The Journal of the American Society of Hematology . 2018,第NovaelaTreatmentAppr期

机译：CRISPR / CAS9敲入HL60细胞密切模拟ELANEASSOCIED NEVEROPENIA的细胞和功能异常; 用MK-0339中性粒细胞弹性蛋白酶抑制剂拯救表型
4. THE SYNTHESIS OF NEUTROPHIL ELASTASE INHIBITOR LYS44349-2H4 AND ITS METABOLITE, LY575481-2H4 [C] . Cheryl S. Mattingly, Boris A. Czeskis, William J. Wheeler International Symposium on the Synthesis and Applications of Isotopes and Isotopically Labelled Compounds . 2004

机译：中性粒细胞弹性蛋白酶抑制剂Lys44349- 2H4的合成及其代谢物，LY575481- 2H4
5. Aberrant subcellular targeting of the G185R neutrophil elastase mutant associated with severe congenital neutropenia induces premature apoptosis of differentiating promyelocytes, and, Expression and function of the transient receptor potential 2 (TRPM2) ion channel in dendritic cells. [D] . Massullo, Pam. 2007

机译：与严重的先天性中性粒细胞减少症相关的G185R中性粒细胞弹性蛋白酶突变体的异常亚细胞靶向诱导分化的早幼粒细胞的过早凋亡，以及树突状细胞中瞬时受体电位2（TRPM2）离子通道的表达和功能。
6. Role of neutrophil elastase in LTB4-induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice [O] . R E Young, M-B Voisin, S Wang, 2007

机译：用特异性抑制剂和中性粒细胞弹性蛋白酶缺陷小鼠评估中性粒细胞弹性蛋白酶在LTB4诱导的中性粒细胞体内迁移中的作用
7. Effects of a synthetic protease inhibitor (gabexate mesilate) and a neutrophil elastase inhibitor (sivelestat sodium) on acid-induced lung injury in rats [O] . Sumiko Yoshikawa, Kenji Tsushima, Tomonobu Koizumi, 2010

机译：合成蛋白酶抑制剂（Gabexate Mesilate）和中性粒细胞弹性蛋白酶抑制剂（Sivelestat钠）对大鼠酸性肺损伤的影响

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