AML drug resistance: C-Myc comes into play

摘要

In this issue of Blood, Nanbakhsh et al show that leukemic cell lines rendered resistant to cytarabine display a higher expression of the natural killer (NK) group 2, member D (NKG2D) ligands (NKG2DL) UL-16 binding proteins 1-3 (ULBP1-3). This expression is c-Myc dependent as it is abrogated by c-Myc inhibitors or small interfering RNA. Consequently, upregulation of NKG2DL renders the cell lines more sensitive to NK-cell-mediated lysis.