Does the NO/sGC/cGMP/PKG pathway play a stimulatory role in platelets?

摘要

In their recent paper, Zhang and collaborators claim that they have identified a stimulatory role of soluble guanylyl cyclase (sGC) in platelets using platelet-specific sGC-deficient mice.1 These data are in contrast to numerous studies by many different investigators in the field of sGC research and to our recent publications. We studied both a global sGC knockout (KO) mouse2 and exactly the same platelet-specific sGC KO3 mouse model as that reported by Zhang et al.