Development of a High-Performan Integrated and Disposable Clarification Solution for Continuous Bioprocessing

摘要

Current bioprocesses combine fed-batch cell culture with batch-wise downstream processing steps. To achieve integrated upstream and downstream continuous manufacturing, the industry has been in need of a continuous cell separation and clarification solution for bioprocess fluids from bioreactors. The Cadence Acoustic Separator from Pall Life Sciences provides this solution, with continuous first-stage clarification without the need for filter media in a scalable, single-use format with no negative impact on product attributes. The Cadence Acoustic Separator delivers cost and time savings through reductions in buffer volumes, filter preparation time, and depth-filter requirements with stable performance and higher yields over longer processing times.