Inactivated Poliovirus Vaccine Made in Modular Facilities with Single-Use Technology: Potential for Local, Sustainable Production in Low- and Middle-Income Countries

摘要

If current efforts to eradicate polioviruses worldwide are successful, then the oral poliovirus vaccine (OPV) currently used for routine immunization in low- and middle-income countries (LMICs) will be replaced by inactivated poliovirus vaccine (IPV). IPV will become the only option for such countries if they want to continue to vaccinate against polio (l). Because IPV is currently considered to be too expensive for use in LMICs, strategies are being undertaken to make IPV more affordable (2). Some experts estimate that in 5-10 years there will be a lack of IPV manufacturing capacity worldwide (3). That will most affect LMICs, which depend on external vaccine supplies. So expansion of existing facilities (or building new ones) will be key to meetfuture demand. Here we examine the use of alternative technologies such as modular manufacturing facilities and single-use equipment as means to improve IPV affordability and capacity.