Cell Harvesting of Biotechnological Processes By Depth Filtration Effects of System Design and Operating Mode on Scalability

摘要

In the pharmaceutical industry, there is a strong desire to introduce new drugs on the market as fast as possible (time-to-market) due to time-limited patent protection for new pharmaceutical products. The thinking behind this desire is simple: The sooner a new product can be introduced to the market, the sooner patients can benefit, and the better are the manufacturer's prospects of financial returns. This consideration, however, should not allow compromises to enter into the manufacturing process design. This article provides an example of how good process design can both optimize and expedite the harvesting of cells in a biotechnological process.