A 12-year-old girl had fever, headache, nausea, and a papular and bullous rash of 4 days' duration. The rash initially appeared on the dorsal surfaces of the hands and feet and spread centrally to involve most of her body surface.Three weeks earlier, she presented with multiple small abscesses on her abdomen and was treated with a 10-day course of trimethoprim/sulfamethoxazole (TMP/SMX) for methicillin-resistant Staphylococcus aureus infection. This was her first exposure to TMP/ SMX or any sulfa-containing medication. She had no known allergies.
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