Chromatographic Purification in Downstream Processing: New Sorbents and Membranes for Process Chromatography

摘要

In many biopharmaceutical companies, chromatographic purification in downstream processing is a key focus for optimization studies. The objective is to streamline the process, which may be achievedby the elimination of intermediate unit operations. The main question, therefore, is how to optimize the adjustment of individual chromatographic process steps.Currently there is a broad range of next-generation sorbents and membranes available for process chromatography. These new chromatography media are characterized by significantly improved performance compared to their classical predecessors: e.g., higher dynamic binding capacities, higher operational flow rates, and specific and distinctive retention mechanisms.