Development of a Novel Cold-Chain Tubing, FP-FLEX~(TM), and Single-Use Freezing Bag:For Working Cell Banks Enabling Closed-System Processing to Temperatures As Low As -196 °C

摘要

Working cell banks (WCBs) are commonly applied to initiate cell culture manufacturing campaigns to produce therapeutic proteins. Those campaigns typically begin with the inoculation of cells previously cryopreserved in vials. Although vials are typically used to establish WCBs and initiate manufacturing campaigns, they are not optimal for the growing demands of commercial production.