Bioreactor Design for Adherent Cell Culture -The Bolt-On Bioreactor Project, Part 1: Volumetric Productivity

摘要

The Bolt-on Bioreactor (BoB) project is an independent initiative aimed at developing and commercializing a bioreactor for efficient, automated culture of adherent cells in production of therapeutic cells and other biopharmaceuticals (l). After conducting thorough research on available culture systems for adherent cells, the BoB team believes that a successful alternative to existing devices must solve four major challenges. The first challenge has to do with volumetric productivity, the second withprocess automation, the third with containment and sterility, and the fourth with process economics. This is the first of four articles addressing each of those challenges and describing design features incorporated into the BoB project in development toovercome them.