Cost Estimation for Protein A Chromatography:An In Silico Approach to MAb Purification Strategy

摘要

Monoclonal antibody (MAb) production has adopted an accepted technology platform for downstreamprocessing (l). The need for more economic processes has been addressed by increasing MAb titers in fermentation and aiming toward greater bioreactor volumes to increase productivity. Consequently, cost pressures are now passed on to downstream process groups. Membrane and chromatography resin savings are more important for MAb processes than ever before, with highly productive cell cultures generating large volumes of process fluid topurify (2).