A BICYCLO[3.2.1]OCTANOID NEOLIGNAN AND TOXICITY OF THE ETHANOL EXTRACT FROM THE FRUIT OF ОСОТЕ A HETEROCHROMA

摘要

A new bicyclo[3.2.1.]octanoid neolignan rel-(7S,8R,1'S,2'S,3'S)-Δ2'-hydroxy-5,1',3'-trimethoxy-3,4-methylenedioxy-7,3',8.1'-neolignan (1) was isolated from ethanol extract from the fruit of Ocotea heterochroma Mez & Sodiro ex Mez as well as the known compounds β-friedelanol (2), meso-dehydroguaiaretic acid (3), and yangambin (4), whose structures were elucidated on the basis of their comprehensive spectroscopic analysis including 2D NMR data. Lethality bioassay using brine shrimp {Artemia salina Leach) was evaluated with the ethano! extract from the Ocotea heterochroma's fruit. The toxicity of this extract was greater than the toxicity of those fractions obtained in a first solvent partition (benzene, ethyl acetate, and butanoi subfractions) and that of a mixture of acetylated 2'-epimers from the new neolignan 1.