Remote ischaemic preconditioning of the heart: remote questions, remote importance, or remote preconditions?

摘要

Options and clinical solutions to decrease damage to the heart in ischaemia/reperfusion settings such as recent myocardial infarction, unstable angina, coronary artery interventions, and cardiac surgery have long been a holy grail for physiologists, cardiologists, cardiac surgeons, and anaesthetists alike. Specifically, the concepts of somehow "conditioning" a heart to attenuate ischaemia/reperfusion-related injury or even to expand the magnitude of tolerable injury have evolved over the last decades from attenuation of (secondary) injury evoked by reperfusion, over ischaemic preconditioning (and postconditioning) and anaesthetic preconditioning, to remote ischaemic preconditioning (RIPC), as attested by a myriad of papers, editorials, grants, and symposia.