Clinical translation of cardioprotective strategies: Report and recommendations of the Hatter Institute 5th International Workshop on Cardioprotection

摘要

The 5th Hatter Institute International Workshop on Cardioprotection was held in South Africa in April of this year. Leading experts in the field of cardioprotection assembled to discuss and debate the recent developments in this exciting area of research, focusing primarily on the translation of novel experimental cardioprotective strategies into clinical therapy. Interest in the early myocardial reperfusion phase as a target for cardioprotection has been regenerated by the publication of several small high-profile 'proof-of-concept' clinical studies on cardioprotection [3, 5, 31, 32, 47, 48].However, despite the publication of these promising clinical trials, it is generally agreed that there is still plenty of scope for further improving the process of translating experimental cardioprotective strategies into clinical therapy, an ongoing issue of concern which has been highlighted in several recent articles [9, 33, 51]. In this respect, discussion and debate focused on proposing a series of recommendations, the implementation of which by both laboratory and clinical researchers working alongside each other,should lead to improvements in the translational process.