Mechanism of action of agomelatine: A novel antidepressant exploiting synergy between monoaminergic and melatonergic properties

摘要

ISSUE:A striking and unexpected pharmacologic synergy has been shown between antagonist actions at serotonergic 5HT2C receptors, and agonist actions at melatonergic receptors by agomelatine, a drug that has both of these properties.