Experimental studies (in vitro) on polyene macrolide antibiotics with special reference to hamycin against Malassezia ovale.

摘要

Hamycin activity in vitro against M. ovale [M. furfur] was studied and compared with old and newly discovered polyene antifungal antibiotics. Hamycin showed a marked anti-M. furfur activity, which was enhanced in the presence of divalent cations like Cu2+ and Zn2+. Furthermore, the absorption of hamycin onto the cell membrane or cell surface of M. furfur was also increased in the presence of divalent cations. It is suggested that hamycin alone or along with metal ions, specifically Cu2+ may be useful clinically in the treatment of dandruff or seborrhoeic dermatitis.