Generation of reactive forms of oxygen by polymorphonuclear leucocytes during hepatoma growth in the rat peritoneal cavity

摘要

In the present work, an attempt was made to analyse generation of reactive oxygen species (ROS) by polymorphonuclear leucocytes (PMN) in the course of turnout growth, using chemiluminescence (CL). A multiple increase in the capacity of polymorphonuclear leucocytes of generating acitve forms of oxygen in the course of tumor growth was discovered. Two causes of this process were found. 1) the increase in specific activity of leucocytes; 2) the increase in the total quantity of PMN circulating in the blood. Leucocytes were also found in the ascite liquid. PMN leucocytes were shown to participate in the antitumor defence of the organism.