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首页> 外文期刊>Clinical and experimental dermatology >The alpha-melanocyte-stimulating hormone-melanocortin receptor system influences the effects of ultraviolet A on skin and intestinal immunity in mice.
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The alpha-melanocyte-stimulating hormone-melanocortin receptor system influences the effects of ultraviolet A on skin and intestinal immunity in mice.

机译:α-黑素细胞刺激激素-黑皮质素受体系统影响紫外线A对小鼠皮肤和肠道免疫的影响。

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摘要

Irradiation by ultraviolet (UV) A is known to decrease Langerhans cells (LCs) in the skin and increase IgA expression in the intestine, specifically the jejunum. These changes were induced in C57BL/6j mice by exposure of the ear or the eyes to 11 J/cm2 UVA radiation, then a melanocortin receptor agonist (Agouti-related protein; AgRP) was introduced either intracerebrally or intracerebroventricularly. The degree of change in both LC number and IgA expression induced by UVA eye irradiation was reduced more by intracerebral than by intraperitoneal injection of AgRP. alpha-Melanocyte-stimulating hormone and melanocortin receptors in the brain seem to contribute to immunomodulation after UVA irradiation of the eye or the ear in mice.
机译:已知通过紫外线(UV)A照射可减少皮肤中的Langerhans细胞(LC),并增加肠(特别是空肠)中的IgA表达。通过将耳朵或眼睛暴露于11 J / cm2 UVA辐射,在C57BL / 6j小鼠中诱导了这些变化,然后在大脑或脑室内引入了黑皮质素受体激动剂(Agouti相关蛋白; AgRP)。由UVA眼照射引起的LC数量和IgA表达的变化程度,与通过腹膜内注射AgRP相比,通过大脑减少的更多。大脑中的α-黑素细胞刺激激素和黑皮质素受体似乎对小鼠的眼睛或耳朵进行UVA照射后有助于免疫调节。

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