Anti-atherosclerotic potential of baicalin mediated by promoting cholesterol efflux from macrophages via the PPAR gamma-LXR alpha-ABCA1/ABCG1 pathway

摘要

Background: Atherosclerosis (AS) is associated with severe cardiovascular disease. The antiinflammatory, anti-oxidation, and lipid regulating properties of baicalin suggest potential as an antiatherosclerotic agent. We therefore investigated whether baicalin can protect against the development of atherosclerosis in an AS rabbit model and explored the underling mechanisms in THP-1 macrophages.