The development of drugs or biomaterials needs the assistance of massive animal experiments. Recently, people disapprove the behavior of forcing animals to suffer pains. If we can develop a cell-based biochip by integrating microfluidic control, cell culture and fabrication techniques of noninvasive sensors, the response of a living organism to extrinsic stimulations can be directly and fast realized. It will be helpful to minimize the animal experiments and become a hot issue in biotechnology fields. In the article, the principles, present development and practical applications of a cell-activity estimation chip are described.
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