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Paeoniflorin ameliorates renal function in cyclophosphamide-induced mice via AMPK suppressed inflammation and apoptosis

机译:eon药苷通过AMPK抑制炎症和凋亡改善环磷酰胺诱导的小鼠的肾功能

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摘要

The study is to investigate the effects of paeoniflorin (PA) on renal function in cyclophosphamideinduced mice. Mice were injected with intraperitoneal cyclophosphamide (CYP, 200 mg/kg) or saline respectively. Mice were treated with PA (15, 30 mg/kg/day) or vehicle for the next 7 days. Then, mice were sacrificed to analyze the biochemical, histological parameters and mechanism research. Our results shown that PA significantly decreased the urine levels of uric acid and creatinine, serum and kidney levels of cytokines such as interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha), PA also obviously attenuated the histological changes of the kidney tissues caused by CYP. Moreover, Western blot demonstrated that PA increased the AMPK levels and inhibited NF-kappa B signaling pathway and apoptosis in CYP-stimulated kidney tissues. In conclusion, PA might be considered as an effective agent in the amelioration of the kidney toxicity resulting from CYP treatment. (C) 2016 Published by Elsevier Masson SAS.
机译:该研究旨在探讨pa药苷(PA)对环磷酰胺诱导的小鼠肾功能的影响。分别给小鼠腹膜内注射环磷酰胺(CYP,200 mg / kg)或生理盐水。在接下来的7天内,用PA(15、30mg / kg /天)或赋形剂处理小鼠。然后,处死小鼠以分析其生化,组织学参数和机理研究。我们的结果表明,PA显着降低尿液中尿酸和肌酐水平,血清和肾脏中诸如白细胞介素6(IL-6),白细胞介素1β(IL-1 beta)和肿瘤坏死因子α( TNF-α),PA也明显减轻了CYP引起的肾脏组织的组织学变化。此外,Western印迹表明,PA可以增加CYP刺激的肾组织中AMPK的水平,并抑制NF-κB信号通路和细胞凋亡。总之,PA可能被认为是改善CYP治疗所致肾脏毒性的有效药物。 (C)2016由Elsevier Masson SAS发布。

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