Development and Application of Functionalized Nanoparticles on Mass Spectrometry for the Analysis of Target Biomolecules

摘要

In recent studies, nanomaterials show the excellent performance in diverse fields. Due to the high surface area to volume ratio, nanomaterials obviously improve the sensitivity and efficiency compared with conventional micro-scaled materials. Combined with matrix-assisted laser desorption/ionization mass spectrometry (MALDI), functionalized nanoparticles established a rapid and reliable platform for various biomolecules extraction and analysis, from cell to protein and small molecule. In this article, we will introduce several important works done by Taiwan research groups and the new developed technique "nanoprobe-based affinity mass spectrometry" (NBAMS) by our group.