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Effect of polysaccharide extracted from Glaciecola polaris on the protection of mouse macrophages from oxidative injury

机译:北极极子多糖提取物对小鼠巨噬细胞氧化损伤的保护作用

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The effect of the protein-bound polysaccharide extracted from Glaciecola polaris (PSG) was investigated in vitro in the protection of oxidatively-injured mouse macrophages stressed by tert-butyl hydroperoxide (tbOOH) or by oxidatively modified low-density lipoprotein (Ox-LDL). The results showed that PSG treatments to protect the macrophages from oxidative injury was effective and the macrophage colony-stimulating factor (M-CSF) exhibited some similar effects. It was speculated that both M-CSF and PSG could protect macrophages from oxidative injury. The results suggested that the effects of PSG were associated with its capability of inducing M-CSF expression. (c) 2005 Elsevier Ltd. All rights reserved.
机译:体外研究了从极地极树(PSG)中提取的结合蛋白质的多糖在保护叔丁基过氧化氢(tbOOH)或氧化修饰的低密度脂蛋白(Ox-LDL)所致的氧化损伤小鼠巨噬细胞中的作用。结果表明,PSG处理能够保护巨噬细胞免受氧化损伤,并且巨噬细胞集落刺激因子(M-CSF)表现出相似的作用。据推测,M-CSF和PSG均可以保护巨噬细胞免受氧化损伤。结果表明,PSG的作用与其诱导M-CSF表达的能力有关。 (c)2005 Elsevier Ltd.保留所有权利。

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