Extraction of sulcal medial surface and classification of Alzheimer's disease using sulcal features

摘要

Background: Recent advancements in medical imaging have resulted in a significant growth in diagnostic possibilities of neurodegenerative disorders. Neuroanatomical abnormalities of the cerebral cortex in Alzheimer's disease (AD), the most frequent type of dementia in the elderly, can be observed in morphology analysis of cortical sulci, and used to distinguish between cognitively normal (CN) subjects and subjects with AD.