Structure elucidation of benzopyran-2-ol in solution and in solid stae following the reduction of coumarin by DIBAL-H

摘要

Lactols are compounds of increasing interest inthe synthesis of active pharmaceutical derivatives.Never the less,the product obtained by the reduction of the carbonyl group of coumarin has been described only twice,and without definition of its precise chemical structure.Since these studies,doubts have been raised about the existence of a monomeric or dimeric form.Our study has led us to conclude definitely that the single dimeric form exists and to precisely definethe spectral properties of the two diastereoisomers.