ONE-POT THREE-COMPONENT MANNICH-TYPE REACTION CATALYZED BY TRIFLUOROMETHANESULFONIC ACID IN WATER

摘要

One-pot three-component Mannich-type reaction of ketones, aldehydes and amines was efficiently cata-lyzed by liquid trifluoromethanesulfonic acid in water at ambient temperature. The high yield of correspond-ing β-amino ketones compounds were achieved. The proposed method is mild, green, simple and efficient.