Detection of molecular characteristics of selective affection of tissues and target-cells in periodic peritonitis (familial mediterranean fever)

摘要

A selective cytotoxic effect of lymphocytes made in patients with periodic peritonitis (PP) on the growth processes clearly observed in tissue cultures of the kidneys and adrenal and observed, to a less extent, in such tissues of the spleen and liver was studied. The above facts are undeniably confirmed by diversified sophisticated immunological research targeted, on the one hand, at detecting a higher sensitivity to the renal antigen and, aimed, on the other hand, at establishing a degree of the biggest reduction of the functional T-lymphocytes' activity in amyloidosis complications. The mentioned data are also reliably confirmed by the methods of histology- and electron microscopy monitoring of autopsy material from the kidneys of PP patients with amyloidosis. The findings provide, to a certain extent, explanations for lesions in the kidneys with amyloidosis in 20-40 percent of cases, for a reduced functional activity in the adrenal cortex and especially in OCS as well as for hepatolienal syndrome, which is typical of PP.