SYNTHESIS, STRUCTURES, AND ANTIBACTERIAL ACTIVITY OF SCHIFF-BASE COBALT(III) COMPLEXES

摘要

Two new Schiff-base cobalt(III) complexes, [CoL~1(En)N_3]Cl (I) and [CoL~2N_3(OH_2)] (II), where L~1, L~2, and En are 2-[1-(2-aminoethylimino)ethyl]phenolate, bis(5-chlorosalicylidene)ethane-1,2-diamine, and 1,2-ethylenediamine, respectively, have been prepared and characterized by physicochemical methods and single crystal X-ray determination. Complex I crystallizes in monoclinic system space group P2_1 with a = 7.113(1), b = 21.385(1), c = 10.599(1) ?, β = 106.067(2)°, V = 1549.2(3) ?~3, Z = 4, R_1 = 0.0322, and wR_2 = 0.0800. Complex II crystallizes in monoclinic system space group P2_1/c with a = 1.679(1), b = 11.145(1), c = 12.493(1) ?, β = 110.553(2)°, V = 1783.5(2) ?~3, Z = 4, R_1 = 0.0360, and wR_2 = 0.0838. Single crystal X-ray diffraction analysis reveals that the Co atoms in the complexes are six-coordinated in octahedral geometry. The complexes were screened in vitro for their antibacterial activity against Bacillus subtillis, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruguinosa.