Lower hemoglobin concentrations and subsequent decline in kidney function in an apparently healthy population aged 60 year and older.

摘要

BACKGROUND: Anemia and decreased kidney function are recognized as risk factors for morbidity and mortality in the elderly. The role of hemoglobin in renal function changes among elderly patients is not fully understood. METHODS: Of 1500 people screened, 121 normotensive non-diabetic elderly patients were recruited, and underwent biochemistry examinations at the baseline, second and fourth years of a 4-year longitudinal study. Serum creatinine and calculated renal parameters, including the Cockroft-Gault (CG) formula, Modification of Diet in Renal Disease (MDRD) Study and abbreviated MDRD (abMDRD) equations were used to evaluate renal function and progression of kidney disease. Chronic kidney disease (CKD) was defined as a glomerular filtration rate (GFR) of <60 ml/min/1.73 m(2). Multivariate regression analyses were used to explore predictors for decline in renal parameters. RESULTS: Ages ranged from 60 to 81 year (mean: 71.8+/-3.8). Baseline hemoglobin concentrations ranged from 11.9 to 17.3 g/dl (mean: 14.1+/-1.1). Serum creatinine increased and CG creatinine clearance (CrCl), MDRD and abMDRD GFR decreased during follow-up (all p