Bioactive Polymeric Systems with Platelet Antiaggregating Activity for the Coating of Vascular Devices

摘要

The preparation, characterization, and analysis of physicochemical and biological properties of a new bioactive polymer system, based on a copolymer of an acrylic derivative of triflusal (a molecule with chemical structure related to aspirin with antiaggregating activity for platelets) is described and evaluated as thin bioactive coating for vascular grafts and coronary stents. The acrylic monomer derived from triflusal (THEMA) provides random copolymers when it is polymerized with butyl acrylate (BA), according to their reactivity ratios, r_(THEMA) = 1.05 and r_(BA) = 0.33. The copolymer THBA70, containing a molar composition f_(THEMA) = 0.45 and f_(BA) = 0.55 presents the optimal properties of stability, flexibility, and adhesion, with a T_g = 21 ± 2 °C, to be applied as bioactive and bioStable coatings for vascular grafts and coronary stents. Thin films of this copolymer system present an excellent biocompatibility and a good inherent antiaggregant activity for platelets.