Chitosah Nanofibers from an Easily Electrospinnable UHMWPEO-Doped Ghitosan Solution System

摘要

Conversion of natural biopolymer chitosan into nanofibers through electrospinning has significant usefulness in various biomedical applications,in particular,for constructing a biomimetic and bioactive nanofibrous artificial extracellular matrix for engineering various tissues.Here,we show that introduction of an ultrahigh-molecular-weight poly(ethylene oxide)(UHMWPEO)into aqueous chitosan solutions remarkably enhances the formation of chitosan nanofibrous structure and leads to much lower loading of the water soluble fiber-forming aiding agent of PEO down to 5 wt % as compared to previous high PEO loadings in the electrospun chitosan nanofibers.The excellent electrospinnability of the current formulation renders electrospinning of natural biopolymer chitosan a robust process for large-scale production of practically applicable nanofibrous structures.