Blood compatible graphene/heparin conjugate is simply formulated through noncovalent interaction between chemically reduced graphene and heparin. Charge repulsion of negatively charged heparin on graphene plates renders hydrophobic graphene to be solublized in aqueous media without any precipitation or aggregation even after 6 months. Unfractioned heparin (UFH) with higher molecular weight was effective for graphene solubilization while low molecular weight heparin (LMWH) was not. Noncovalently interacting heparin chains on graphene plates preserve their anticoagulant activity after conjugation with graphene. Graphene/UFH conjugate shows much enhanced ami factor Xa (FXa) activity of 29.6 IU/mL compared with pristine graphene oxide (GO; 1.03 IU/mL).
展开▼
机译：通过化学还原的石墨烯与肝素之间的非共价相互作用，可以简单地配制血液相容性石墨烯/肝素共轭物。石墨烯板上带负电荷的肝素的电荷排斥力使疏水性石墨烯即使在6个月后也能在水性介质中溶解而没有任何沉淀或聚集。分子量较高的普通肝素（UFH）对石墨烯增溶有效，而低分子量肝素（LMWH）无效。与石墨烯缀合后，石墨烯板上的非共价相互作用的肝素链保留了其抗凝活性。与原始氧化石墨烯（GO; 1.03 IU / mL）相比，石墨烯/ UFH共轭物显示29.6 IU / mL的增强的ami因子Xa（FXa）活性。
展开▼
