High Antimicrobial Effectiveness with Low Hemolytic and Cytotoxic Activity for PEG/Quaternary Copolyoxetanes

摘要

The alkyl chain length of quaternary ammo-nium/PEG copolyoxetanes has been varied to discern effects on solution antimicrobial efficacy, hemolytic activity and cytotoxicity. Monomers 3-((4-bromobutoxy)methyl)-3-methyloxetane (BBOx) and 3-((2-(2-methoxyethoxy)ethoxy)methyl)-3-meth-yloxetane (ME2Ox) were used to prepare precursor P-[(BBOx)(ME2Ox)-50:50~4 kDa] copolyoxetane via cationic ring opening polymerization. The 1:1 copolymer composition and M_n (4 kDa) were confirmed by ~1H NMR spectroscopy. After C—Br substitution by a series of tertiary amines, ionic liquid Cx-50 copolyoxetanes were obtained, where 50 is the mole percent of quaternary repeat units and V is quaternary alkyl chain length (2, 6, 8, 10, 12, 14, or 16 carbons). Modulated differential scanning calorimetry (MDSC) studies showed T_gs between -40 and -60 °C and melting endotherms for C14-50 and C16-50.