Surface-Initiated,Atom Transfer Radical Polymerization of Oligo(ethylene glycol)Methyl Ether Methacrylate and Subsequent Click Chemistry for Bioconjugation

摘要

The uncontrolled,nonspecific adsorption and adhesion of biological materials(e.g.,proteins and cells)onto synthetic surfaces causes a complex cascade of undesired events and bioincompatibility problems in the applications of biomaterials.A number of studies on materials,such as polysaccharides,dextran,cellulose dialysis membranes,5 and poly(ethylene glycol)(PEG),have pursued the elimination/minimization of the unwanted,nonspecific adhesion of biological entities;but the verification of complete rejection to any protein adsorption remains a challenge.