Water-Soluble Poly(ethylenimine)-Based Nitric Oxide Donors:Preparation,Characterization,and Potential Application in Hemodialysis

摘要

A novel approach to potentially resolve serious thrombosis issues associated with kidney dialysis (hemodialysis) therapies is described.New water-soluble polymeric nitric oxide (NO) donors,based on the diazeniumdiolated branched poly(ethylenimine)s and their derivatives,are prepared and characterized.These macromolecular NO donors (with up to 4.15 mu mol/mg of total NO release) are utilized as additives to the dialysate solution of model dialysis filters.The presence of these species can create a localized increase in NO levels at the high surface area dialysis fiber/blood interface within the hemodialyzers.Nitric oxide is a naturally occurring and potent anti-platelet agent and is expected to greatly decrease the risk of thrombosis in the dialysis units.