Thermo-and pH-responsive biodegradable poly(alpha-N-substituted gamma-glutamine)s

摘要

New double stimuli-responsive poly(alpha-N-substituted gamma-glutamine) has been developed,which was synthesized by the reaction of poly(gamma-glutamic acid) with amino alcohols.Appropriate combinations of the amino alcohols provided the biodegradable poly(amino acid) exhibiting a sharp lower critical solution temperature (LCST) in water.Furthermore,the phase transition temperature was highly sensitive to pH changes.