Can exercise partly cure the cardiorenal syndrome?

摘要

Chronic heart failure (CHF) can lead to chronic renal injury and loss of renal function. This presentation has been termed cardiorenal syndrome type 2.[1] The presence of proteinuria and histological signs of renal injury in this condition show that chronic renal failure is not merely a consequence of reduced renal perfusion, but can truly be characterized as chronic kidney disease (CKD).[2, 3] Characteristic of both CHF and CKD is depressed production of nitric oxide (NO).[4, 5] Hence, exogenous NO administration in experimental cardiorenal syndrome using a tolerance-free NO donor could indeed partially rescue cardiac function and ameliorate renal injury.[6] An alternative strategy to increase endogenous NO production is exercise training (ET).[7]